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OALib Journal期刊

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Targeting the Tumour: Cell Penetrating Peptides for Molecular Imaging and Radiotherapy
Veerle Kersemans,Bart Cornelissen
Pharmaceuticals , 2010, DOI: 10.3390/ph3030600
Abstract: Over the last couple of years, the number of original papers and reviews discussing various applications of cell penetrating peptides (CPPs) has grown exponentially. This is not remarkable since CPPs are capable of transporting the most varying cargo across cell membranes which is one of the biggest problems in drug delivery and targeted therapy. In this review, we focus on the use of CPPs and related peptides for delivery of imaging contrast agents and radionuclides to cells and tissues with the ultimate goal of in vivo molecular imaging and molecular radiotherapy of intracellular and even intranuclear targets.
ALVIC versus the Internet: Redesigning a Networked Virtual Environment Architecture
Peter Quax,Jeroen Dierckx,Bart Cornelissen,Wim Lamotte
International Journal of Computer Games Technology , 2008, DOI: 10.1155/2008/594313
Abstract: The explosive growth of the number of applications based on networked virtual environment technology, both games and virtual communities, shows that these types of applications have become commonplace in a short period of time. However, from a research point of view, the inherent weaknesses in their architectures are quickly exposed. The Architecture for Large-Scale Virtual Interactive Communities (ALVICs) was originally developed to serve as a generic framework to deploy networked virtual environment applications on the Internet. While it has been shown to effectively scale to the numbers originally put forward, our findings have shown that, on a real-life network, such as the Internet, several drawbacks will not be overcome in the near future. It is, therefore, that we have recently started with the development of ALVIC-NG, which, while incorporating the findings from our previous research, makes several improvements on the original version, making it suitable for deployment on the Internet as it exists today.
111In-BnDTPA-F3: an Auger electron-emitting radiotherapeutic agent that targets nucleolin
Bart Cornelissen, Andrew Waller, Carol Target, Veerle Kersemans, Sean Smart, Katherine A Vallis
EJNMMI Research , 2012, DOI: 10.1186/2191-219x-2-9
Abstract: F3 was labeled with fluorescein isothiocyanate (FITC) for confocal microscopy and conjugated to p-SCN-benzyl-diethylenetriaminepentaacetic acid (BnDTPA) for labeling with 111In to form 111In-BnDTPA-F3. MDA-MB-231-H2N (231-H2N) human breast cancer cells were exposed to 111In-BnDTPA-F3 and used in cell fractionation, γH2AX immunostaining (a marker of DNA double-strand breaks), and clonogenic assays. In vivo, biodistribution studies of 111In-BnDTPA-F3 were performed in 231-H2N xenograft-bearing mice. In tumor growth delay studies, 111In-BnDTPA-F3 (3 μg, 6 MBq/μg) was administered intravenously to 231-H2N xenograft-bearing mice once weekly for 3 weeks.Membrane-binding of FITC-F3 was observed in 231-H2N cells, and there was co-localization of FITC-F3 with nucleolin in the nuclei. After exposure of 231-H2N cells to 111In-BnDTPA-F3 for 2 h, 1.7% of 111In added to the medium was membrane-bound. Of the bound 111In, 15% was internalized, and of this, 37% was localized in the nucleus. Exposure of 231-H2N cells to 111In-BnDTPA-F3 (1 μM, 6 MBq/μg) resulted in a dose-dependent increase in γH2AX foci and in a significant reduction of clonogenic survival compared to untreated cells or cells exposed to unlabeled BnDTPA-F3 (46 ± 4.1%, 100 ± 1.8%, and 132 ± 7.7%, respectively). In vivo, tumor uptake of 111In-BnDTPA-F3 (3 μg, 6 MBq/μg) at 3-h post-injection was 1% of the injected dose per gram (%ID/g), and muscle uptake was 0.5%ID/g. In tumor growth delay studies, tumor growth rate was reduced 19-fold compared to untreated or unlabeled BnDTPA-F3-treated mice (p = 0.023).111In-BnDTPA-F3 is internalized into 231-H2N cells and translocates to the nucleus. 111In-BnDTPA-F3 has a potent cytotoxic effect in vitro and an anti-tumor effect in mice bearing 231-H2N xenografts despite modest total tumor accumulation.Targeted radiotherapy uses alpha-, beta-, or Auger electron emissions from radionuclides to specifically irradiate cancer cells and cause tumor growth arrest. Well-established examples
Coupled Electromagnetic Circuits and Their Connection to Quantum Mechanical Resonance Interactions and Biorhythms  [PDF]
W. Ulmer, G. Cornelissen
Open Journal of Biophysics (OJBIPHY) , 2013, DOI: 10.4236/ojbiphy.2013.34031
Abstract:

The existence of specific biorhythms and the role of geomagnetic and/or solar magnetic activities are well-established by appropriate correlations in chronobiology. From a physical viewpoint, there are two different accesses to biorhythms to set up connections to molecular processes: quantum mechanical perturbation theoretical methods and their resonance dominators to characterize specific interactions between constituents. These methods permit the treatment of molecular processes by circuits with characteristic resonances and “beat-frequencies”, which result from primarily fast physical processes. As examples, the tunneling processes between DNA base pairs (H bonds), the ATP decomposition and the irradiation of tumor cells are accounted for.

Climate change and its effects on terrestrial insects and herbivory patterns
Cornelissen, T;
Neotropical Entomology , 2011, DOI: 10.1590/S1519-566X2011000200001
Abstract: climate change and extreme weather events affect plants and animals and the direct impact of anthropogenic climate change has been documented extensively over the past years. in this review, i address the main consequences of elevated co2 and o3 concentrations, elevated temperature and changes in rainfall patterns on the interactions between insects and their host plants. because of their tight relationship with host plants, insect herbivores are expected to suffer direct and indirect effects of climate change through the changes experienced by their host plants, with consequences to population dynamics, community structure and ecosystem functioning.
Class field theory as a dynamical system
Gunther Cornelissen
Mathematics , 2011,
Abstract: This is the text from a talk at the Arbeitstagung 2011, which can serve as an introduction to arxiv:1009.0736 and arXiv:1007.0907. I first discuss how a global field is determined by a certain dynamical system, and how this relates to abelian L-series determining those fields. I then discuss an analog in Riemannian geometry, and how it leads to a metric in the space of closed Riemannian manifolds.
Curves, dynamical systems and weighted point counting
Gunther Cornelissen
Mathematics , 2012, DOI: 10.1073/pnas.1217710110
Abstract: Suppose X is a (smooth projective irreducible algebraic) curve over a finite field k. Counting the number of points on X over all finite field extensions of k will not determine the curve uniquely. Actually, a famous theorem of Tate implies that two such curves over k have the same zeta function (i.e., the same number of points over all extensions of k) if and only if their corresponding Jacobians are isogenous. We remedy this situation by showing that if, instead of just the zeta function, all Dirichlet L-series of the two curves are equal via an isomorphism of their Dirichlet character groups, then the curves are isomorphic up to "Frobenius twists", i.e., up to automorphisms of the ground field. Since L-series count points on a curve in a "weighted" way, we see that weighted point counting determines a curve. In a sense, the result solves the analogue of the isospectrality problem for curves over finite fields (also know as the "arithmetic equivalence problem"): it says that a curve is determined by "spectral" data, namely, eigenvalues of the Frobenius operator of k acting on the cohomology groups of all l-adic sheaves corresponding to Dirichlet characters. The method of proof is to shown that this is equivalent to the respective class field theories of the curves being isomorphic as dynamical systems, in a sense that we make precise.
The 2-primary class group of certain hyperelliptic curves
Gunther Cornelissen
Mathematics , 1999,
Abstract: Let G be the separable Galois group of a finite field F of characteristic p, and X/F an imaginary hyperelliptic curve such that G acts transitively on its set W(X) of Weierstrass points. The existence of a G-invariant 2-torsion point on the Jacobian J(X) of X depends only on the parity of |W(X)|, but for large enough |F|, there exist two such curves X and X' with |W(X)|=|W(X')|, such that J(X) has (and J(X') does not have) a G-invariant 4-torsion point. The problem is equivalent to a study of the 2-,4- and 8-rank of the class number of the maximal order in the function field of such curves, and is investigated via the 2-primary class field tower. Contrary to the case of number fields, the ambiguous class depends on the discriminant, and a governing field for the 8-rank of such function fields is not known.
Regulation 1231/2010 on the inclusion of third
Rob Cornelissen
- , 2018, DOI: 10.1177/1388262718771784
Abstract: The EU regulations on the coordination of social security systems provide a high standard of protection for people moving within the EU. For a long time, third-country national workers have been excluded from this protection. This article shows that the explanation for this exclusion is to be found in the legal basis of the EU regulations. This article also demonstrates how developments in primary law in the last two decades have paved the way for the extension of the EU regulations to third-country nationals. Regulation 1231/2010 offers third-country nationals, in the field of social security, the same protection as EU citizens moving within the EU. However, this extension is subject to two conditions. For this reason, a considerable number of third-country nationals working in a Member State do not benefit from equal treatment as nationals of the host State. The article clarifies why Regulation 1231/2010 does not apply in Norway, Iceland, Liechtenstein, Switzerland and Denmark. Attention is paid to a number of challenges and open questions, such as the special position of the UK and the relationship between Regulation 1231/2010 and bilateral agreements concluded between a Member State and a third country
Imagining Futures for Organization Studies: The Role of Theory and of Having Productive Conversations towards Theory Change
Joep Cornelissen
- , 2019, DOI: 10.1177/0170840618767468
Abstract:
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